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Pathological studies in degenerating neurons have demonstrated that S-nitrosylation of Drp1 specifically mediates aberrant mitochondrial recruitment, thereby triggering cascade activation of PINK1/PARKIN pathway-mediated mitophagy (Li et al., 2019)

The cytoprotective transcription factor Nrf2 was strongly activated in glutathione-deficient keratinocytes, but additional loss of Nrf2 did not aggravate the phenotype, demonstrating that the cytoprotective effect of Nrf2 is glutathione dependent

Furthermore, Elevated aspartate levels drive tumor proliferation by facilitating the synthesis of both nucleotides and asparagine [215, 216] (Table 9)

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