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Data show that in adult patients with type 2 diabetes with increased cardiovascular (CV) risk, compared with titrated insulin glargine, all three doses of tirzepatide show superiority in reducing blood sugar and body weight: treatment for 52 weeks, with curative effect Estimation (efficacy estimand) statistical analysis method, the highest dose of tirzepatide (15 mg, once a week) reduces blood glucose level (A1C) from baseline by 2.58%, and weight from baseline by 11.7 kg (25.8 pounds, 13.0%), and titration Insulin glargine reduced A1C from baseline by 1.44% and body weight increased by 1.9 kg (4.2 lbs, 2.2%) from baseline

13 The clinical expert suggested that, if these clinical and biochemical criteria are not supported by a genetic diagnosis (mutations in the GHR gene [Laron syndrome], post-GHR signalling pathway dysfunction, and IGF-1 gene defects) or by the presence of GH antibodies, treatment decisions should be informed by a panel of clinical experts to avoid misdiagnosis and overtreatment

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