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The sequence is proline-rich, with three consecutive prolines followed by a fourth at position eight, and that conformationally constrained backbone is the usual structural explanation offered for the resistance

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For larger changes (US to Europe, 6 to 9 hours), consider: Option 1: Inject at your normal body-clock time (8 AM Los Angeles time = 5 PM Paris time) Option 2: Inject at your normal clock time in the new zone (8 AM Paris time) and accept the 9-hour early dose Option 2 is fine for a one-week trip