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In the APP/PS1 mouse model of Alzheimer's disease-related amyloidopathy, long-term dietary supplementation with spermidine has been shown to decrease neuroinflammation and significantly decrease the levels of toxic, soluble amyloid-beta (A) (229)

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In a six-month trial of patients with primary biliary cholangitis, daily doses of 500mg, 1000mg, or 1500mg of TUDCA shifted bile composition toward more hydrophilic bile acids, including higher UDCA levels a profile believed to be less toxic to liver cells.31 Overall, TUDCA has been shown to improve blood tests linked to bile buildup, but it hasnt yet been proven to prevent cirrhosis or improve long-term survival