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Fixed costs decrease 20 percent: Total profit would increase $1,000,000 (from loss of $100,000 in base case to profit of $900,000 in this scenario)

*A phase 1 study evaluated the pharmacokinetic profile, safety, tolerability, and immunogenicity of the doses of AJOVY tested in the phase 2 and 3 trials (225 mg and 675 mg) following single administration in healthy subjects

The proportion of screening failures ranged from 7% to 30% in PIONEER 1 to 4, 6, 8 to 10

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