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Neurons and microglia can detect and sense cytosolic mtDNA, driving neuroinflammatory responses characterized by cytokine production, inflammasome activation, and recruitment of peripheral immune cells [12]

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Polymorphisms in CYP1A1, CYP1A2, CYP2C8, CYP2E1, CYP2J2, and CYP3A4 are generally less predictive, but data show that predictive variants exist [14]

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