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The proposed mechanism is restoration of normal melatonin production in individuals with age-related decline

[22] Memory performance declines with age

Regarding the refinement for Chc-Apl2.1 we have included secondary structure restraints, NCS torsion restrains, TLS refinement (at the beginning of the refinement one per chain and after the initial cycles the different TLS groups were calculated using phenix), grouped Bfactor refinement using PHENIX (1.21_5207) 58,59