Access and affordability are significant challenges, as are governmental policies, such as the current prohibition on Medicare coverage for weight loss medications in the US, restrict availability for many individuals who could benefit from these therapies
NOW Foods and HUM Nutrition deserve some nods for efficacy, too
When you lose weight, your metabolism adjusts downward to conserve energy, and hunger-regulating hormones like ghrelin rebound to defend your new (lower) weight
Last reviewed: July 17, 2026 Last updated: July 17, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations