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This is important because HFpEF is a diverse condition with different underlying causes than HFrEF, and therapies effective in HFrEF have not always been successful in HFpEF.8,31,32 While prior reviews may have given importance to conventional endpoints like mortality and HF hospitalization, our study emphasis the significance of symptom burden and functional status, which are crucial for living with HFpEF.33 Prior analyses of GLP-1RAs in HFpEF have yielded insightful information, however, they have some limitations

Moreover, both NE and DA inhibited glutathione depletion-associated MAPKs activation, p53 phosphorylation and GADD45 activation