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Peer review Peer review information Nature Reviews Endocrinology thanks Geltrude Mingrone, Alex Miras, Pirjo Nuutila and Antonio Ettore Pontiroli for their contribution to the peer review of this work

Riboflavin (vitamin B2) has been well studied in this regard, with high doses (400 mg/day) shown to decrease attack frequency, possibly through enhancements in mitochondrial energy metabolism