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Although direct comparisons through head-to-head trials like Retatrutide vs tirzepatide have not been completed, the mixed results hint at Retatrutide's superior efficacy in helping weight loss

Week-by-week dosage comparison Weight loss comparison at matched timepoints *Tirzepatide 24 and 48-week figures estimated from SURMOUNT-1 trajectory data, as primary endpoint was 72 weeks

Two-year sustained weight loss and metabolic benefits with controlled-release phentermine/topiramate in obese and overweight adults (SEQUEL): a randomized, placebo-controlled, phase 3 extension study