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Patients on these combination regimens may require dose adjustments of concurrent diabetes medications to prevent low blood sugar episodes

Clathrin Box mutations decrease Ent1-Abp1 endocytic events To evaluate the impact of mutations in the Clathrin boxes during endocytosis, we measured lifetime of Ent1 and Ent2 proteins endogenously tagged with mNeonGreen in the presence of Abp1-mTurquoise2 at endocytic sites by TIRF microscopy

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The researchers found a lower rate of adverse clinical events in the GLP-1 treated group