Malignant Peripheral Nerve Sheath Tumor (MPNST) is an extremely rare tumor (1/100,000) that represents up to 10% of sarcomas, divided into those related to Neurofibromatosis type 1 (NF1), which corresponds to 50% of cases, and sporadic ones.1,2 The most widely accepted hypothesis today is that NF1-related MPNST arises from a neurofibroma that undergoes multiple genetic and phenotypic alterations until transforming into a malignant lesion
Furthermore, it was noted that Nrf2 activation is amplified by SIRT1 signaling 86
Sirajudeen F, Bou Malhab LJ, Bustanji Y et al (2024) Exploring the potential of rosemary derived compounds (rosmarinic and carnosic acids) as cancer therapeutics: current knowledge and future perspectives
Some are labeled for research use only, which means they are not meant to be used for these purposes at alland, most importantly, are not approved for human use