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In people with HF, this is accompanied by a metabolic shift toward water and energy conservation [33], resembling estivation, a physiological adaptation observed in animals during prolonged nutrient and water scarcity [34]

Additional cardiovascular parameters observed with tirzepatide include reductions in systolic and diastolic blood pressure (approximately 57 mmHg systolic reduction) and improvements in lipid profiles, along with substantial weight lossall factors that may influence cardiovascular risk

Agonist medications mimic natural hormones, activating the same receptors

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