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Cai, Y., Xin, Q., Lu, J., Miao, Y., Lin, Q., Cong, W., & Chen, K

Notably, various exendin-4-based GLP-1RAs (Exenatide: 39 aa and Lixisenatide: 44 aa), and GLP-1-based GLP-1RAs (Dulaglutide: 31 aa, Liraglutide: 31 aa, Semaglutide: 31 aa, Tirzepatide: 39 aa, and Albiglutide: 60 aa) have been developed and approved by the FDA between 2005 and 2022 for the management of T2DM (Liu, 2024)

Therefore, the proposed geometric mean cost and payment rate of APC 5464 is almost entirely based on the geometric mean cost of CPT code 64590

The critical pharmacological balance is that the GLP-1R activation offsets the hyperglycemic tendency of glucagon receptor agonism