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The pen or device should be held for the full instruction time, commonly 5-10 seconds depending on the pen

GLP-1 Receptor Activation The GLP-1 receptor component provides effects that have become the cornerstone of modern obesity pharmacotherapy: activation of GLP-1 receptors in the hypothalamus and brainstem powerfully suppresses appetite and induces satiety through effects on proopiomelanocortin (POMC) neurons and other appetite-regulatory circuits, leading to substantial reductions in caloric intake

There were no violations of the proportional hazards assumption (Schoenfeld test p = 0.761, 0.816, and 0.697, respectively)

This new drug has gained significant attention for its weight loss results shown in recent clinical trials