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Fang YQ, Ding H, Li T, Zhao XJ, Luo D, Liu Y, Li Y

Dula also significantly reduced the expression of transforming growth factor-1 (TGF-1), phosphatidylinositol-3-kinase (PI3K), protein kinase B (AKT) signaling pathway, and the inflammatory cytokines: nuclear factor kappa B (NF-B), interleukin-6 (IL-6), and interferon- (IFN-) in colonic cellular structures

They also report a familiar list of issues that prescribers see in trials: severe nausea during titration, persistent fatigue, raised heart rate, and a burning skin sensation that researchers call dysesthesia

Given the heterogeneity of evidence across this field, greater interpretive weight was placed on human studies, well-characterized animal models, and recent high-quality reviews