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Semaglutide constipation treatment options: when to contact a healthcare provider The interventions above work well for many people, but you may need further treatment if you have any of the following symptoms : Severe stomach pain Abdominal swelling Rectal bleeding Inability to pass gas Vomiting These symptoms could indicate a more serious GI issue that requires medical treatment, so seek medical attention if you experience them, or if you have other side effects youd like to discuss

That's not the same as "unsafe," but it is meaningfully different from picking up brand-name Zepbound at a retail pharmacy

The result is that you become dehydrated

[30] [31] A systematic review published in 2024 found that tirzepatide is well tolerated and not associated with pancreatitis, [32] but later case reports have found that pancreatitis followed initiation of treatment with tirzepatide