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Switching from Semaglutide GLP-1 to tirzepatide may be considered for several reasons

GLP-1s not tied to suicide, self-harm According to Peter Ueda, MD, PhD , an assistant professor at Karolinska Institute in Sweden, and colleagues, the effect of GLP-1 receptor agonists on suicidality is plausible becausre the drugs have been shown to cross the blood-brain barrier. However, they also pointed out how some have hypothesized that GLP-1 receptor agonists could protect against mental illness like depression