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Increased levels of H 2 O 2 was observed in both ibuprofen treated male and female livers relative to controls

By comparison, the addition of digitonin, a detergent used as a positive control, resulted in a large increase in the cytotoxic signal

this, in turn, affected the function of androgen-dependent Sertoli cells and perimyocardial myoblast-like cells, ultimately leading to impaired spermatogenesis