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doi: 10.1210/en.2011-1443

ASO therapy alone was shown to suppress HER-2 protein expression and improve the efficacy of medicines Like taxol, doxorubicin, cisplatin, vinblastine, And 5-fluorouracil, irrespective of intrinsic HER-2 levels

32 If inhibition of the enzyme after digestion is complete using serine protease inhibitors is undesirable, the sample may be applied to a HiTrap benzamidine column to remove the enzyme from the sample