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Muscle tissue burns more calories at rest than fat, so losing muscle mass can slow your metabolic rate and make long-term weight maintenance harder after treatment ends

To further characterize compound engagement of TGR in ex vivo worms using an orthogonal assay, inhibition of TGR activity in newly transformed schistosomula (NTS, skin-stage worms) was assessed using a TrxR-selective fluorescent probe 43,44 , TRFS-Green

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