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Molecular Sciences, 2018)

Impact of reverse micelle loaded lipid nanocapsules on the delivery of gallic acid into activated hepatic stellate cells: a promising therapeutic approach for hepatic fibrosis

In a primary culture of orbital fibroblasts from GO patients and control subjects treated with H 2 O 2 to induce OS, the antioxidants vitamin C, N-acetyl-L-cysteine, melatonin, retinol, -carotene and vitamin E were found to reduce the manifestations OS (proliferation of fibroblasts, the level of hyaluronic acid, the level of tumor necrosis factor- (TNF-), IFN- and IL1-, which provided the basis for the possible clinical use of these substances in patients with GO (87)

Others, like correction of anemia or nerve symptoms, might take a few weeks of consistent therapy