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Corticotropin-releasing hormone induces skin mast cell degranulation and increased vascular permeability, a possible explanation for its proinflammatory effects

Furthermore, certain medications, such as some laxatives and drugs used to treat tuberculosis, can also cause this effect

It has been reported that matrix metalloprotease (MMP) enzymes are responsible for the proteolytic degradation of ECM, and they play a role in invasion and metastasis due to the high expression of these MMPs in various tumor tissues (Kleiner and Stetler-Stevenson 1999)

As you say them, they're very deep when you really like think about them