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Mucositis, Periodontitis & Gut-Oral Axis KPV is particularly relevant for patients with refractory periodontitis, pericoronitis, chemotherapy-induced oral mucositis, or chronic low-grade gingival inflammation unresponsive to conventional scaling
The most studied mechanisms include: upregulation of growth hormone receptors in fibroblasts (increasing sensitivity to healing signals), activation of the FAK-paxillin pathway (promoting cell adhesion and migration), modulation of the nitric oxide system through Src-Caveolin-1-eNOS phosphorylation (enhancing vascular function), and dual activation of the Egr-1/NAB2 gene loop (promoting organized, non-chaotic blood vessel growth)
Children born to mothers with low B12 levels may have excess fat accumulation which in turn can result in higher insulin resistance and risk of T2D and/or CVD in adulthood
Rickes 1948 Rickes EL, Brink NG, Koniuszy FR, Wood TR, Folkers K
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