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Consumer interest appears driven by several factors: Convenience factors that consumers cite include the elimination of pill-swallowing, no need for water or food timing, and discrete all-day wear

Moreover, quantitative sex-related differences in therapeutic response and adverse effects highlight the need for sex-stratified analyses, which are still lacking in pediatric studies

Most researchers begin noticing appetite suppression at the 5 mg level, with significant weight loss typically beginning around weeks 8-12 as doses increase