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10.1152/ajprenal.00259.2012 175

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This increase in the Bcl-2/Bax ratio stabilizes the mitochondrial membrane, prevents cytochrome c release, and enhances cell survival [54,55,56]

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Additional physiological roles in pancreatic islets, the brain, bone, and peripheral tissues have since been identified, and disturbances in incretin signaling are now considered to contribute to the pathogenesis of T2DM (Mller et al., 2019)

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Safety considerations (hypercalcemia/mineral imbalance) apply to active agents and high-dose bolus regimens

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