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Some small human studies suggest that yerba mate or green mate (same active compound) can be helpful for fat loss and appetite reduction

In this context, the antitumor activity reported for incretin-based polyagonists should not be interpreted as evidence for GCGR agonism alone, but rather as an indication that coordinated multi-receptor targeting may induce favorable systemic metabolic remodeling (62,63)

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Vyvanse, on the other hand, is a stimulant pro-drug