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The absorption pathway itself is intact in these patients

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Kaufman et al., 2014

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3.4 Changes in bone turnover markers Figures 1c,d present percentage changes in CTX and P1NP by group and over time, respectively

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Furthermore, the gastrointestinal tract also has a major role in metformin action through modulation of glucose-lowering hormone glucagon-like peptide 1 and the intestinal bile acid pool and alterations in gut microbiota composition

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