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Wegovy's higher 2.4 mg dose causes diarrhea in approximately 31% of users, while lower Ozempic doses for diabetes affect about 12% of users

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The consistency of findings across multiple retrospective cohorts and data sources provides a compelling signal of efficacy on clinical endpoints, justifying a shift in research focus: the field now needs adequately powered phase 3 randomized controlled trials to validate these preliminary findings [58], define optimal treatment strategies such as dosing and treatment duration, and establish the role of GLP-1 RAs in both acute and long-term management of IIH