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In agreement with the clinical outcomes, markedly lower plasma histamine and IgE levels, augmented IFN-/IL-4 and IL-10/IL-4 ratios, re-methylation of the IL-4 promoter and de-methylation of the IFN- and Foxp3 promoters were observed [39]

Inhibiting HO-1 expression could prevent the degeneration of RPE and photoreceptor cells by decreasing Fe 2+ accumulation

This study was supported by the National Natural Science Foundation of China (grant numbers 81573337) and the Jiangsu Province natural science Foundation project(BK20171319) and Taizhou Science and technology support plan (social development) project(SSF20230019)

doi: 10.1038/s41591-019-0349-y 24 OttMPrinsRMHeimbergerAB