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In particular, the administration of empagliflozin in individuals with prediabetes or diabetes was associated with the amelioration of glycemia and insulin sensitivity and with increased -hydroxybutyrate (BHB) levels

Our findings, using genetic models and isotope tracing, are consistent with a model in which CrAT produces acetylcarnitine from acetyl-CoA in mitochondria and then following export to the cytosol, it converts acetylcarnitine back to acetyl-CoA as an alternative to ACLY for two carbon transfer from mitochondria (Figure 7A)

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These insights provide a framework for precision medicine, where genetic profiling may help refine risk stratification and guide targeted therapeutic strategies