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2.1.4 Impaired intestinal and renal excretion Approximately 90% of patients with gout exhibit impaired uric acid excretion, primarily due to reduced renal urate clearance (Nakayama et al., 2023

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Concluding remarks The mechanisms of APAP-induced liver injury are highly complex and many intracellular and extracellular events are involved in this pathophysiological process, including metabolism of APAP, mitochondrial oxidative stress, ER stress, autophagy, sterile inflammation, microcirculatory dysfunction and liver regeneration