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Selenium, cadmium (Cd), arsenic (As), and lead (Pb) in particular have attracted a lot of study due to their complex relationships with thyroid function and trace elements [3]

On the other hand, Fe(II) ion chelation can significantly influence the properties of flavonoids, such as anti-ROS efficacy, hydrophobicity, and membrane permeability, and, thus, their physiological activity [98,103,104]