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Cellular mechanisms for heavy metal detoxification and tolerance

For peak annotation, the precursor and product ions were annotated based on accurate mass, fragmentation pattern, and isotopic distributions utilizing databases such as the Human Metabolome Database (HMDB) with a mass error 5 ppm, METLIN MS/MS (www.metlin.scripps.edu), LipidMap, Lipid Blast, KEGG [69]

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It has been widely used in anti-aging and cosmetic products in humans for decades without any adverse effects and can be easily incorporated in creams, liposomes, foams or subcutaneous injections