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doi: 10.1177/1756283X16644242 PMCID: PMC4913337 The intestinal microbiome, barrier function, and immune system in inflammatory bowel disease: a tripartite pathophysiological circuit with implications for new therapeutic directions Stephen M

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Another study with CuCl 2 treated Hep G2 cell line demonstrated that mitochondrial toxicity is an intermediate-level event associated with copper toxicity to Hep G2 cells while lysosomal damage is the early event and plasma damage a late feature associated with copper toxicity 34

One of the major contributors to this approach was Lelio Orci (figure 20) based at the University of Geneva