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Each vial is designed to support batch-level verification on arrival

Treatment begins with 0.25 mg once weekly for 4 weeks as an initiation dose (not intended for glycaemic control), then increases to 0.5 mg once weekly

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Thus, expectations for the overall magnitude of effect from a given agent might be modest when treating patients whose baseline A1c is 30 pioglitazone reduced HbA1c levels better than sitagliptin while in individuals with a BMI 90 canagliflozin lowered HbA1c better than sitagliptin while in individuals with an eGFR between 60-90 sitagliptin was more effective (13)