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For example, T cells and B cells in GALT can recognize and eliminate translocated bacteria while simultaneously producing anti-inflammatory cytokines such as IL-10 to sustain intestinal immune tolerance (134, 135).Moreover, innate immune cells recognize pathogen-associated molecular patterns via pattern recognition receptors (e.g., Toll-like receptors) and activate signaling pathways like NF-B, thereby modulating the intensity and duration of the immune response (136)

These medications can cause side effects in some patients

Further research should assess a larger cohort size to confirm that A-T disease progression is attenuated upon NR supplementation

Blots were further incubated with anti-rabbit horseradish peroxidase (HRP)-conjugated secondary antibody (1:5000, 31460, Thermo Scientific) for 2 h at room temperature, and immunoreactive bands were detected using the enhanced chemiluminescence (ECL) method in a ChemiDoc XRS System (BioRad) with Image Lab software