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It is completely reversible

& Al Somaie, M

He notes he is not chasing lifespan extension but uses it for the mental and physical performance increase

Nitric oxide, a gaseous neurotransmitter, is synthesized from L-arginine through different isoforms of nitric oxide synthase (NOS): Neuronal (nNOS), endothelial (eNOS), and inducible (iNOS) (7)