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These medications work through analgesic synergy, meaning their combined effect is greater than the sum of their individual parts

10.1073/pnas.95.17.9914 [DOI] [PMC free article] [PubMed] [Google Scholar] White J

However, further research is needed to validate these findings, examine the exact mechanisms underlying these interactions, and explore the long-term clinical efficacy and safety of this combination for managing diabetic CKD in humans