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Lactate dehydrogenase (LDH) cytotoxicity assays revealed negligible loss of cell viability in 25HC-treated FAK KO macrophages or macrophages treated with a FAK inhibitor (Supplementary Table 1)

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An important theoretical concern exists: c-Met is overexpressed in multiple human cancers (gastric, lung, colorectal), and chronic c-Met pathway stimulation could potentially influence cancer riskthough this has not been studied longitudinally even in animals

N-3 PUFAs enhance VDR expression by attenuating neuroinflammation 105,110,111 , and activating the Nrf2 pathway, which mitigates oxidative stress-linked VDR suppression 112,113,114