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Histamine Overload and MCAS Flares: As a key component of Phase II liver detoxification, glutathione accelerates the clearance of circulating histamine and inflammatory cytokines, helping to reduce flushing, itching, and sudden allergic-like reactions

VallejoCordoba, A

22 This inhibition reduces the local inflammatory response, creating a more conducive environment for tissue regeneration by limiting the recruitment of inflammatory cells that could otherwise contribute to tissue damage

Verdict at a Glance Cortistatin has the superior mechanistic profile, with a well-defined receptor pharmacology, clear sleep-promoting mechanism through cortical synchronization, and endogenous homeostatic sleep factor properties