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Influencia ainda, indiretamente, o metabolismo glicdio e proteico: a oxidao dos cidos graxos reduz a utilizao perifrica da glicose, uma vez que permite a entrada de acetilas no ciclo de Krebs, aumentando consequentemente a disponibilidade energtica da clula

Chang J, Wu T, Greenfield JR, Samocha-Bonet D, Horowitz M, Rayner CK

These neurological symptoms require urgent medical attention, as prolonged B12 deficiency can lead to irreversible nerve damage

2.2 Key Patent Expiry Dates and Early Launches For GLP-1 drugs, patent timing has played a critical role: Indian government and ICMR documents note that, as a concrete milestone, the core patent for semaglutide expired on March 20, 2026, triggering immediate generic launches and a sharp price drop across India.[4] According to Business Standard, more than 40 Indian drugmakers including Sun Pharma, Dr