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4 Neurotrophic factors and neuroprotective strategies 4.1 BDNF/TrkB signaling pathway The therapeutic relevance of the BDNF/TrkB pathway is further supported by TrkB agonist studies in noise-induced hearing loss models, which are highly relevant to tinnitus

Central nervous pathways of insulin action in the control of metabolism and food intake

Some clinicians hypothesise that these medications might also affect saliva composition or flow, though this remains speculative

November 2025: Although vision loss is an uncommon side effect of tirzepatide drugs like Mounjaro, some people who take the drug experience this life-altering side effect