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The enzyme glutathione reductase can convert GSSG back to GSH using NADPH as a cofactor, which is an important part of cellular defenses against oxidative stress

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For heavy long-term drinkers, significant cravings can persist for six to twelve months, and low-level situational cravings can resurface for years when triggered by stress or environmental cues

At the same time, there was an increasing focus on the potentially harmful effects of lipid peroxidation (Heath and Packer 1968), growing awareness that optimal activities of photosynthetic enzymes required a highly reducing environment (Wolosiuk and Buchanan 1977