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The existing evidence base consists primarily of: Small observational studies in patients with diabetes who also have inflammatory conditions Mechanistic studies exploring theoretical anti-inflammatory pathways Indirect evidence from cardiovascular outcome trials showing reduced inflammatory markers in people with type 2 diabetes (which cannot be extrapolated to rheumatoid arthritis or to microdosing) NICE guidance for rheumatoid arthritis management (NG100) does not include GLP-1 receptor agonists among recommended treatment options

Dr Sudhir Kumar MD DM (@hyderabaddoctor) January 23, 2023 As such, we reached out to experts to understand the role of vitamin B12, its deficiency, and whether it is possible to overdose on supplements or injections

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