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Based primarily on preclinical studies with limited human confirmation, GLP-1 receptors appear enriched in regions involved in autonomic control, feeding behavior, reward processing, and cognitive function

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Patients on maintenance doses retained 70 to 85% of their peak weight loss at two years, compared to 40 to 60% retention for those who stopped completely but implemented lifestyle changes, and less than 30% for those who stopped without significant lifestyle modification

Reduced appetite = reduced intake = increased risk of missing key nutrients like: Protein Iron, calcium, magnesium, zinc, potassium, choline, folate