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Simultaneously, disturbed level of miR-21 was observed in diverse neuropathic pain models (Zhong et al., 2019) where it targets metalloproteinase-3 (TIMP3) and chemokines C-C motif ligand 1 (CCL1) that consequently evoke cytokine production of TNF-, IL-1, and IL-6 and aggravate neuroinflammation

Methods Animals Animal experiments were performed with adherence to all national and local guidelines and regulations, the Guide for the Care and Use of Laboratory Animals 25 , and the ARRIVE guidelines, and with the approval of the Institutional Animal Care and Use Committee at The University of Texas Medical Branch (UTMB)