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While current redox proteomics in CF often focuses on identifying which proteins are modified (e.g., carbonylated, glutathionylated), techniques like FPOP offer the potential to delve deeper into how these modifications occur - identifying specific residues targeted by ROS - and how these modifications, or the oxidative environment itself, impact protein structure, dynamics, and interactions (Johnson et al., 2019

however, initial small human studies have been disappointing 12

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Key Studies and Findings Clinical Trials on Systemic Oxidative Stress Biomarkers A placebo-controlled trial demonstrated that glutathione significantly improved systemic oxidative stress biomarkersand glutathione production in patients with chronic illnesses