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Durante el ejercicio, una produccin excesiva de cido lctico aumenta la acidez de la sangre y el lquido tisular, reduce la generacin de ATP y provoca fatiga

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FASEB J 10(4):471480 Chiku T, Padovani D, Zhu W, Singh S, Vitvitsky V, Banerjee R (2009) H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia

By restricting mPTP opening, these agents reduce mitochondrial swelling and rupture, thereby limiting the release of DAMPs, including mtDNA